6 Napier Rd, #02-10 Gleneagles Medical Centre, Singapore 258499 +65 8849 0677 baselneurosurgery@bone.com.sg
Book appointmentBook

Home  /  Conditions  /  Muscle breakdown

Muscle breakdown (rhabdomyolysis)

Damaged muscle releasing its contents into the blood, where they can harm the kidneys. Severe muscle pain with dark, tea-coloured urine needs to be seen the same day — during opening hours, call us first, and we can arrange admission to Gleneagles Hospital if you need it.

A man holding his side and stomach while describing his symptoms to a doctor who is taking notes on a tablet.
What it is
Muscle breaking down and releasing myoglobin, potassium and other contents into the blood.
The warning sign
Severe muscle pain or weakness with dark, tea- or cola-coloured urine.
Where it is treated
In hospital, with intravenous fluids. We can assess you and arrange admission.

Suspected rhabdomyolysis: get seen today

Muscle pain or weakness after exercise, an injury or a long period lying still needs to be checked the same day if it comes with any of these:

  • Dark urine — tea- or cola-coloured
  • Passing much less urine than usual
  • Pain, swelling or weakness far beyond normal soreness
  • Nausea, vomiting, fever, confusion or feeling very unwell
  • A limb that is tense, swollen and extremely painful, especially with numbness — this can be compartment syndrome, which needs emergency surgery

During our opening hours, call us on +65 8849 0677. We will assess you the same day and, if you need hospital treatment, admit you directly to Gleneagles Hospital or its emergency department.

Outside opening hours, go to an emergency department. We are open Monday to Friday 9am to 5:30pm, and Saturday 9am to 1pm. If symptoms are severe or getting worse quickly, call 995. Tell the doctor what exercise, injury or medicines came before it.

Call +65 8849 0677

What is rhabdomyolysis?

Rhabdomyolysis — often shortened to rhabdo — is the rapid breakdown of damaged skeletal muscle. As the muscle cells break down, they release their contents into the bloodstream.

Two of those contents cause most of the danger. Myoglobin, the protein that holds oxygen in muscle, can block and damage the kidneys, and is what turns urine dark. Potassium, released in large amounts, can disturb the heart’s rhythm. With early treatment, most people recover fully, including their kidney function.

Normal soreness, or rhabdomyolysis?

Muscles ache after hard or unfamiliar exercise, and almost always that is normal. These are the differences that matter.

 Normal sorenessRhabdomyolysis
When it comes on12 to 24 hours after exercise, peaking at one to three daysDuring or soon after, and can keep getting worse
How it feelsStiff and tender; eases with gentle movementSevere pain out of proportion, with swelling and marked weakness
Using the muscleUncomfortable but possibleStruggling to stand, climb stairs, or straighten the arms
UrineNormal colourDark, tea- or cola-coloured; often less of it
What to doRest, gentle movement, fluidsSame-day assessment: call us in opening hours, otherwise an emergency department

Dark urine after exercise can also come from dehydration. But dark urine together with severe muscle pain or weakness should be treated as rhabdomyolysis until a blood test shows otherwise.

Rhabdomyolysis symptoms

  • Muscle pain, often in the thighs, calves, lower back or upper arms
  • Muscle weakness and swelling
  • Dark, tea- or cola-coloured urine, and passing less of it
  • Nausea, vomiting and tiredness
  • Fever, confusion or agitation in more severe cases

Symptoms can be mild, or delayed. Some people notice little beyond sore muscles, and the classic dark urine is not always present. Where the history fits — an unaccustomed hard workout, heat, a crush injury — a blood test is what settles it.

What causes it

Exercise

  • Intense or unaccustomed exercise — spin, high-intensity classes, heavy squats, long runs
  • Exercising in heat, or while dehydrated
  • Military and uniformed-service training

Injury and pressure

  • Crush injuries and serious accidents
  • Lying on the floor for hours after a fall
  • Compartment syndrome

Medicines and substances

  • Statins, rarely, and more so with some other medicines
  • Heavy alcohol use
  • Recreational drugs such as cocaine and amphetamines

Illness and other causes

  • Heatstroke, and some infections such as influenza
  • Very low potassium or phosphate levels
  • Inherited muscle conditions, suspected when episodes recur

How rhabdomyolysis is diagnosed

Diagnosis is made in hospital, mainly with blood and urine tests.

  • Creatine kinase (CK) — an enzyme released from damaged muscle. In rhabdomyolysis it is usually many times above normal
  • Kidney function, potassium and calcium — to see whether the kidneys or heart are at risk
  • Urine test — can show myoglobin
  • ECG — to check for the effect of high potassium on the heart
  • Further tests later — only for repeated or unexplained episodes, such as genetic or muscle tests

Rhabdomyolysis treatment

Treatment happens in hospital, and starting it early is what protects the kidneys.

Intravenous fluids

The main treatment: generous fluids through a drip to flush myoglobin through the kidneys, with urine output and blood tests checked closely.

Correcting the blood chemistry

High potassium is treated quickly because of its effect on the heart. Other salts are monitored and corrected as needed. Any medicine that may have contributed is reviewed.

Dialysis, if the kidneys fail

A minority need temporary dialysis while the kidneys recover. Most regain normal kidney function.

Surgery for compartment syndrome

If pressure builds dangerously inside a muscle compartment, an emergency operation (fasciotomy) releases it to save the muscle and limb.

Recovery and returning to exercise

  • Rest from strenuous exercise until symptoms have settled and blood tests, including CK and kidney function, are back to normal.
  • Build back gradually over several weeks, starting well below your previous level.
  • Drink enough, and avoid training hard in heat while you rebuild.
  • A second episode needs investigating, as it can point to an underlying muscle condition.

Where our clinic fits

Rhabdomyolysis is treated in hospital. During opening hours, our orthopaedic surgeons can assess a suspected case the same day and, if you need treatment, admit you directly to Gleneagles Hospital. After you have been discharged, they can also help with what follows:

  • Muscle or tendon injuries from the same workout or accident
  • Pain, stiffness or weakness that is slow to settle
  • A safe plan for returning to training or sport
  • Other injuries from the same fall or accident

Common questions

Is rhabdomyolysis an emergency?

Yes. It can damage the kidneys and disturb the heart’s rhythm, so severe muscle pain or weakness with dark urine needs to be seen the same day. During opening hours, call us: we can assess you and arrange admission to Gleneagles Hospital. Outside opening hours, go to an emergency department.

Can a spin or gym class cause it?

Yes. Intense or unfamiliar exercise is one of the commonest causes, especially in the first session of a new class, in heat, or when dehydrated. Building intensity gradually lowers the risk.

Is dark urine after exercise always rhabdomyolysis?

No. Dehydration can darken urine too. But dark urine together with severe muscle pain or weakness should be checked the same day.

Can I exercise again?

Most people return to full activity. Wait until symptoms have settled and blood tests are normal, then build up gradually over several weeks.

Can statins cause rhabdomyolysis?

Rarely. Do not stop a prescribed statin on your own, but tell your doctor promptly about unexplained muscle pain or weakness, especially with dark urine.

Do I need a referral?

No. For suspected rhabdomyolysis during opening hours, call us and we will see you the same day; outside opening hours, go to an emergency department. For follow-up after hospital, bring your discharge summary and blood test results.

Related conditions

Myofascial pain · Back pain · Knee pain · Hip pain

Book a consultation

For suspected rhabdomyolysis, call rather than book online so we can see you the same day. For follow-up after hospital, bring your discharge summary.

Book an appointment Call +65 8849 0677
Address
6 Napier Road, #02-10
Gleneagles Medical Centre
Singapore 258499
Phone
+65 8849 0677
Mon–Fri
9:00 am – 5:30 pm
Saturday
9:00 am – 1:00 pm
Book an appointment Choose a doctor & time